Antimicrobial Therapy and Vaccines
نویسندگان
چکیده
منابع مشابه
Immunomodulators as adjuvants for vaccines and antimicrobial therapy.
A highly effective strategy for combating infectious diseases is to enhance host defenses using immunomodulators, either preventatively, through vaccination, or therapeutically. The effectiveness of many vaccines currently in use is due in part to adjuvants, molecules that have little immunogenicity by themselves but which help enhance and appropriately skew the immune response to an antigen. T...
متن کاملGenetic Vaccines and Therapy
Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little is known concerning lambda phage-mediated gene transfer and expression in mammalian hosts. We therefore performed experiments to evaluate lambda-ZAP bacteriophage-mediated gene transfer a...
متن کاملGenetic Vaccines and Therapy
Background: Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens. Objective: To evaluate effects and potential mechanisms of DNA vaccine containing ovalbumin (OVA) and Fc fusion on allergic airway inflammation. Methods: Bronchoalveolar lavage (BAL) levels of inflammatory mediators and ...
متن کاملGenetic Vaccines and Therapy
Background: The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown to enhance drug delivery to bones. Methods: In this study six-L aspartic acids (D6) were inserted into the AAV2 capsid protein sequence between amino acid residues 587 and 588...
متن کاملGenetic Vaccines and Therapy
The complexity of parasitic infections requires novel approaches to vaccine design. The versatility of DNA vaccination provides new perspectives. This review discusses the use of prime-boost immunizations, genetic adjuvants, multivalent vaccines and codon optimization for optimal DNA vaccine design against parasites. Introduction DNA vaccination was introduced in 1990 by a study that demonstrat...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1999
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/44.2.305